La maladie de Parkinson au Canada (serveur d'exploration)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Dopamine Antagonism Decreases Willingness to Expend Physical, But Not Cognitive, Effort: A Comparison of Two Rodent Cost/Benefit Decision-Making Tasks

Identifieur interne : 000A90 ( Main/Exploration ); précédent : 000A89; suivant : 000A91

Dopamine Antagonism Decreases Willingness to Expend Physical, But Not Cognitive, Effort: A Comparison of Two Rodent Cost/Benefit Decision-Making Tasks

Auteurs : Jay G. Hosking [Canada] ; Stan B. Floresco [Canada] ; Catharine A. Winstanley [Canada]

Source :

RBID : PMC:4330516

Abstract

Successful decision making often requires weighing a given option's costs against its associated benefits, an ability that appears perturbed in virtually every severe mental illness. Animal models of such cost/benefit decision making overwhelmingly implicate mesolimbic dopamine in our willingness to exert effort for a larger reward. Until recently, however, animal models have invariably manipulated the degree of physical effort, whereas human studies of effort have primarily relied on cognitive costs. Dopamine's relationship to cognitive effort has not been directly examined, nor has the relationship between individuals' willingness to expend mental versus physical effort. It is therefore unclear whether willingness to work hard in one domain corresponds to willingness in the other. Here we utilize a rat cognitive effort task (rCET), wherein animals can choose to allocate greater visuospatial attention for a greater reward, and a previously established physical effort-discounting task (EDT) to examine dopaminergic and noradrenergic contributions to effort. The dopamine antagonists eticlopride and SCH23390 each decreased willingness to exert physical effort on the EDT; these drugs had no effect on willingness to exert mental effort for the rCET. Preference for the high effort option correlated across the two tasks, although this effect was transient. These results suggest that dopamine is only minimally involved in cost/benefit decision making with cognitive effort costs. The constructs of mental and physical effort may therefore comprise overlapping, but distinct, circuitry, and therapeutic interventions that prove efficacious in one effort domain may not be beneficial in another.


Url:
DOI: 10.1038/npp.2014.285
PubMed: 25328051
PubMed Central: 4330516


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Dopamine Antagonism Decreases Willingness to Expend Physical, But Not Cognitive, Effort: A Comparison of Two Rodent Cost/Benefit Decision-Making Tasks</title>
<author>
<name sortKey="Hosking, Jay G" sort="Hosking, Jay G" uniqKey="Hosking J" first="Jay G" last="Hosking">Jay G. Hosking</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Department of Psychology, University of British Columbia</institution>
, Vancouver, BC,
<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Floresco, Stan B" sort="Floresco, Stan B" uniqKey="Floresco S" first="Stan B" last="Floresco">Stan B. Floresco</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Department of Psychology, University of British Columbia</institution>
, Vancouver, BC,
<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Winstanley, Catharine A" sort="Winstanley, Catharine A" uniqKey="Winstanley C" first="Catharine A" last="Winstanley">Catharine A. Winstanley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Department of Psychology, University of British Columbia</institution>
, Vancouver, BC,
<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">25328051</idno>
<idno type="pmc">4330516</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330516</idno>
<idno type="RBID">PMC:4330516</idno>
<idno type="doi">10.1038/npp.2014.285</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000013</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000013</idno>
<idno type="wicri:Area/Pmc/Curation">000013</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000013</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000501</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000501</idno>
<idno type="wicri:Area/Ncbi/Merge">001944</idno>
<idno type="wicri:Area/Ncbi/Curation">001944</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001944</idno>
<idno type="wicri:doubleKey">0893-133X:2014:Hosking J:dopamine:antagonism:decreases</idno>
<idno type="wicri:Area/Main/Merge">000A94</idno>
<idno type="wicri:Area/Main/Curation">000A90</idno>
<idno type="wicri:Area/Main/Exploration">000A90</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Dopamine Antagonism Decreases Willingness to Expend Physical, But Not Cognitive, Effort: A Comparison of Two Rodent Cost/Benefit Decision-Making Tasks</title>
<author>
<name sortKey="Hosking, Jay G" sort="Hosking, Jay G" uniqKey="Hosking J" first="Jay G" last="Hosking">Jay G. Hosking</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Department of Psychology, University of British Columbia</institution>
, Vancouver, BC,
<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Floresco, Stan B" sort="Floresco, Stan B" uniqKey="Floresco S" first="Stan B" last="Floresco">Stan B. Floresco</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Department of Psychology, University of British Columbia</institution>
, Vancouver, BC,
<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Winstanley, Catharine A" sort="Winstanley, Catharine A" uniqKey="Winstanley C" first="Catharine A" last="Winstanley">Catharine A. Winstanley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Department of Psychology, University of British Columbia</institution>
, Vancouver, BC,
<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Neuropsychopharmacology</title>
<idno type="ISSN">0893-133X</idno>
<idno type="eISSN">1740-634X</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>Successful decision making often requires weighing a given option's costs against its associated benefits, an ability that appears perturbed in virtually every severe mental illness. Animal models of such cost/benefit decision making overwhelmingly implicate mesolimbic dopamine in our willingness to exert effort for a larger reward. Until recently, however, animal models have invariably manipulated the degree of physical effort, whereas human studies of effort have primarily relied on cognitive costs. Dopamine's relationship to cognitive effort has not been directly examined, nor has the relationship between individuals' willingness to expend mental
<italic>versus</italic>
physical effort. It is therefore unclear whether willingness to work hard in one domain corresponds to willingness in the other. Here we utilize a rat cognitive effort task (rCET), wherein animals can choose to allocate greater visuospatial attention for a greater reward, and a previously established physical effort-discounting task (EDT) to examine dopaminergic and noradrenergic contributions to effort. The dopamine antagonists eticlopride and SCH23390 each decreased willingness to exert physical effort on the EDT; these drugs had no effect on willingness to exert mental effort for the rCET. Preference for the high effort option correlated across the two tasks, although this effect was transient. These results suggest that dopamine is only minimally involved in cost/benefit decision making with cognitive effort costs. The constructs of mental and physical effort may therefore comprise overlapping, but distinct, circuitry, and therapeutic interventions that prove efficacious in one effort domain may not be beneficial in another.</p>
</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Canada</li>
</country>
</list>
<tree>
<country name="Canada">
<noRegion>
<name sortKey="Hosking, Jay G" sort="Hosking, Jay G" uniqKey="Hosking J" first="Jay G" last="Hosking">Jay G. Hosking</name>
</noRegion>
<name sortKey="Floresco, Stan B" sort="Floresco, Stan B" uniqKey="Floresco S" first="Stan B" last="Floresco">Stan B. Floresco</name>
<name sortKey="Winstanley, Catharine A" sort="Winstanley, Catharine A" uniqKey="Winstanley C" first="Catharine A" last="Winstanley">Catharine A. Winstanley</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A90 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A90 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4330516
   |texte=   Dopamine Antagonism Decreases Willingness to Expend Physical, But Not Cognitive, Effort: A Comparison of Two Rodent Cost/Benefit Decision-Making Tasks
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25328051" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1 

Wicri

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022